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What Are DHT Blockers and How Do They Prevent Hair Loss?

What Are DHT Blockers and How Do They Prevent Hair Loss?

31 Jan, 2023

Until you start researching hair loss (and how to stop it), you don’t hear a lot about DHT. But then, when you do start researching the topic, “DHT” and “DHT blocker” is everywhere. And you finish your internet search with questions that range from “Um, but what is DHT exactly?” to “Can this really stop me from balding?” to “Why didn’t I pay more attention in biology class?”

Long story short: DHT, or dihydrotestosterone, is a male sex hormone that binds to receptors in your scalp and causes hair loss that leads to male pattern baldness (a.k.a. androgenic alopecia) in genetically-susceptible men. DHT blockers are medications and supplements that, yep you guessed it, block DHT.

What exactly is DHT and how is linked to hair loss?

DHT is an androgen (male sex hormone) which is made from testosterone in the prostate, testes, and certain other tissues. It’s needed to develop and maintain male sex characteristics, such as a deep voice, facial hair, and muscles.

Testosterone converts to DHT with the help of 5α-reductase (pronounced 5-alpha-reductase), an enzyme that is held in the oil glands of a hair follicle.

If you’re genetically prone to male pattern baldness, DHT binds to receptors in your hair follicles, causing the follicle to miniaturize (which basically means shrink) and, eventually, to stop new growth altogether.

While research has proven that genetics plays a big role in male pattern hair loss, we still don’t know why this runs in some families and not others.

How long does it take DHT sensitivity to cause total baldness?

The good news is that this doesn’t happen overnight. To fully explain this, we should take a step back to discuss the four stages of hair growth that are always happening on your head:
•  Anagen Phase: The growth phase that usually lasts from two to six years.
•  Catagen Phase: The transition phase that only lasts for a few weeks.
•  Telogen Phase: The resting phase that lasts for about three months.
•  Exogen Phase: The shedding phase that usually results in 100-150 hairs falling out each day.

The hair is lost during the exogen phase when the follicle produces a new hair that pushes out the old one.

As androgenic alopecia sets in, follicles gets smaller and smaller making it harder for hair to grow (thanks DHT), the anagen phase gets shorter (less time for hair to grow), and the telogen phase gets longer (more time for follicle to rest without producing a new hair).

However, baldness is a slowly progressive process that usually takes place over several years.
That means you have time to stop DHT from shrinking those hair follicles and that the earlier you take action, the more hair you’ll keep.

That’s where DHT blockers come in.

Can you tell me more about DHT blockers?

While you can go down an internet rabbit hole and read about all kinds of “DHT blockers,” there’s only one that’s proven to work. And that one is finasteride. Finasteride (generic Propecia®) is a prescription tablet that effectively blocks DHT and stops further hair loss, including receding hairlines. It works by binding to the 5α-Reductase enzyme, effectively inhibiting your body from producing DHT in the first place.

OK—but do DHT blockers really work for hair regrowth?

Yes! DHT blockers are the most effective hair loss treatment. Not only does it halt hair loss, but it can even help with future growth. Another study, this one published by the Journal of Investigative Dermatology, showed that up to 83% of men taking finasteride 1mg preserved their original hair follicle counts and 66% experienced some regrowth. Those are pretty great numbers when it comes to both stopping loss and kickstarting healthy regrowth.

Can I naturally reduce DHT?

Not everyone who wants to lose less hair is ready to get a prescription, and that’s understandable. And the internet will lead you to believe that everything from shampoos to supplements to emu oil can block DHT.

While some potential natural DHT blockers—like biotin, pumpkin seed oil, green tea, and saw palmetto—have big reputations among guys with male pattern hair loss, in clinical studies they have more of a mixed track record.

Despite all the excitement about some natural treatments, the DHT blocker with the most scientific evidence behind it is still finasteride.

Let us recap:

DHT is the primary hormone responsible for male pattern baldness. While there are lots of so-called DHT blockers out there, the only one that’s clinically proven to work is finasteride.
That makes finasteride the best way to prevent hair loss.

Keen on other effective solutions for improved results – there are many! PRP Hair Treatment, Hair Mesotherapy and Laser Hair Therapy on the non-surgical side and Hair Transplant on the surgical side.

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